How to create a strategy to defeat aging?
Let's take a sober look at the situation of the last 30 years. There was an incredible amount of expectations from certain discoveries, but we still do not have such a thing that extended the life of a person to 100 years for most people.
We linked our hopes with various technologies: telomerase activation, oxidative stress inhibitors, longevity genes, senescent cells - there is no desired result.
It was impossible to imagine in 2000 that in 2020, sports and low-calorie nutrition will remain the most effective way to prolong life.
Something went wrong? On the one hand, we often believed in one simple solution. It is understandable - that which fits in one sentence, or better - in one word - is easier to sell.
The telomeric theory has done great harm to the idea of prolonging life, because we thought that the problem was solved simply. With stem cells the same story.
On the other hand, when you ask the question “What should we do?”, The answer most often sounds “We must do everything.”
In the world there are many good ideas on what to do, for example:
- Thymus regeneration
- Study of the effect of mitochondria on immunity
- Stem cell pool restoration and fight against senescent cells
- Improving the functional properties of the intercellular matrix - mechanical medicine
- Implementation of aging diagnostic standards
- Development of a mathematical algorithm for turning genes on and off to extend the life of model animals
- Creating a comprehensive knowledge base on aging
- Institute for the Extension of Life of the Hadron Collider Scale
- Patient-driven research
- Epigenetic rollback
- Creation of a political party
Here you can bring thousands of links, I will give one, about the search for combinations of drugs to prolong life.
The combination of 3 drugs extended the life of fruit flies by 48%. Lithium, trametinib and rapamycin.
www.sciencedaily.com/releases/2019/09/190930161857.htm
Another link about how to search for such combinations on worms:
www.biorxiv.org/content/10.1101/153205v1.full
Literally thousands of ideas are waiting in the wings. But how do we do all this?
To do everything, we have no resources. We must say: “This is what we are doing, this is the most effective step, and we should focus on that. We’re not doing the rest yet. ”
A strategy is not only an action plan, it is a choice between different plans and a rejection of something.
Otherwise, we will always be in the swamp of good wishes. For example, we can say a million times “the government should allocate one hundred billion dollars to extend life”, but this does not and will not happen until we have a clear plan on how we will achieve this.
Moreover, we must do something that has never been undertaken before. What?
Let's imagine a timeline. Here we are now, but somewhere here a radical extension of life. How do we get from point A to point B? What exactly awaits us between points A and B?
We can say with varying degrees of confidence that between A and B there will be:
- Conditional skyscraper for life extension, “hadron collider” of aging - a large-scale international project.
This is an engine of progress, but also an indicator that society has decided to deal with the problem. There is no huge project - that means we are going with the flow.
A boom in education in the biology of aging and longevity. That is, the forerunner of a research institute, real or virtual, should be master's and PhD programs on the topic of life expectancy and aging.
Otherwise, in general, who should work and experiment? This boom may be when we see 1000 hours of an open educational course in the field of aging and longevity.
- Clinical studies of aging therapies
- A variety of public initiatives as a marker of community involvement. For example, CI on the initiative and at the expense of patients.
- Competition of open projects
Let's just look at one more option just in case. A situation where we all die, but we think that we are acting right. The ray also leaves point A, but to point B`, more precisely, B-death.
What events disorient us?
- many reports that a cure for old age is about to be found
- hype in the press
- successful IPO, with the promise of a cure for old age
- fake clinical research.
The charm of capitalism can mislead us: money is spinning, there is movement, there is smoke and thunder all around. But we are in the "lemons market" when buyers are not informed about the quality of goods, bad goods crowd out good ones.
Still, the big difference is whether we have high-quality educational programs or a set of irresponsible advertising statements. What do you think is more in the life extension industry now?
As we move toward the point of B-death.
One cannot talk about serious successes in prolonging life, when there are failures in the treatment and prevention of Alzheimer's and metabolic syndrome.
What do we offer? - fill in all the gaps between A and B in the right order. That is, draw up an action plan.
Let's look at large and small organizations in the fight against aging. Everyone has their own approaches. They are not consistent, and we do not know which is the best. What to do with these strategies? Just wait, who will succeed?
We offer - a public discussion of strategies to defeat aging. Roadmap contest. The closest thing now is to such a public discussion of X-prize, but hardly a degree of discussion corresponds to the importance of the issue.
Let us take the experience of conducting debates and election campaigns and holding the election of the best strategy for defeating aging.
For all this, we have created a resource that will analyze all approaches.
openlongevitystrategy.org
What might the debate look like in defense of a particular strategy? What questions will representatives of organizations answer?
- Are there obvious holes in the strategy? Are there any offers to jump the abyss in one step?
- Is it clear where the project will take the resources to implement the plan? It's about money, and about people, and about ideas.
- Will such a strategy lead to exponential growth in our area? Do not forget, we all live in a state of time pressure.
We also implement our own approach and offer it for criticism and discussion:
openlongevity.org
That is my main idea: let's choose the best approach in the fight against aging. It is important to take part in this.
The idea of prolonging life is often considered to be somehow selfish and self-centered. This is a huge misconception. The idea of extending life is the pinnacle of effective altruism. This is a struggle to save the lives of billions of people. The most important thing in this fight is a quality strategy. In any case, let us do this work together: we will choose and implement the best life extension strategy.
We linked our hopes with various technologies: telomerase activation, oxidative stress inhibitors, longevity genes, senescent cells - there is no desired result.
It was impossible to imagine in 2000 that in 2020, sports and low-calorie nutrition will remain the most effective way to prolong life.
Something went wrong? On the one hand, we often believed in one simple solution. It is understandable - that which fits in one sentence, or better - in one word - is easier to sell.
The telomeric theory has done great harm to the idea of prolonging life, because we thought that the problem was solved simply. With stem cells the same story.
On the other hand, when you ask the question “What should we do?”, The answer most often sounds “We must do everything.”
In the world there are many good ideas on what to do, for example:
- Thymus regeneration
- Study of the effect of mitochondria on immunity
- Stem cell pool restoration and fight against senescent cells
- Improving the functional properties of the intercellular matrix - mechanical medicine
- Implementation of aging diagnostic standards
- Development of a mathematical algorithm for turning genes on and off to extend the life of model animals
- Creating a comprehensive knowledge base on aging
- Institute for the Extension of Life of the Hadron Collider Scale
- Patient-driven research
- Epigenetic rollback
- Creation of a political party
Here you can bring thousands of links, I will give one, about the search for combinations of drugs to prolong life.
The combination of 3 drugs extended the life of fruit flies by 48%. Lithium, trametinib and rapamycin.
www.sciencedaily.com/releases/2019/09/190930161857.htm
Another link about how to search for such combinations on worms:
www.biorxiv.org/content/10.1101/153205v1.full
Literally thousands of ideas are waiting in the wings. But how do we do all this?
To do everything, we have no resources. We must say: “This is what we are doing, this is the most effective step, and we should focus on that. We’re not doing the rest yet. ”
A strategy is not only an action plan, it is a choice between different plans and a rejection of something.
Otherwise, we will always be in the swamp of good wishes. For example, we can say a million times “the government should allocate one hundred billion dollars to extend life”, but this does not and will not happen until we have a clear plan on how we will achieve this.
Moreover, we must do something that has never been undertaken before. What?
Let's imagine a timeline. Here we are now, but somewhere here a radical extension of life. How do we get from point A to point B? What exactly awaits us between points A and B?
We can say with varying degrees of confidence that between A and B there will be:
- Conditional skyscraper for life extension, “hadron collider” of aging - a large-scale international project.
This is an engine of progress, but also an indicator that society has decided to deal with the problem. There is no huge project - that means we are going with the flow.
A boom in education in the biology of aging and longevity. That is, the forerunner of a research institute, real or virtual, should be master's and PhD programs on the topic of life expectancy and aging.
Otherwise, in general, who should work and experiment? This boom may be when we see 1000 hours of an open educational course in the field of aging and longevity.
- Clinical studies of aging therapies
- A variety of public initiatives as a marker of community involvement. For example, CI on the initiative and at the expense of patients.
- Competition of open projects
Let's just look at one more option just in case. A situation where we all die, but we think that we are acting right. The ray also leaves point A, but to point B`, more precisely, B-death.
What events disorient us?
- many reports that a cure for old age is about to be found
- hype in the press
- successful IPO, with the promise of a cure for old age
- fake clinical research.
The charm of capitalism can mislead us: money is spinning, there is movement, there is smoke and thunder all around. But we are in the "lemons market" when buyers are not informed about the quality of goods, bad goods crowd out good ones.
Still, the big difference is whether we have high-quality educational programs or a set of irresponsible advertising statements. What do you think is more in the life extension industry now?
As we move toward the point of B-death.
One cannot talk about serious successes in prolonging life, when there are failures in the treatment and prevention of Alzheimer's and metabolic syndrome.
What do we offer? - fill in all the gaps between A and B in the right order. That is, draw up an action plan.
Let's look at large and small organizations in the fight against aging. Everyone has their own approaches. They are not consistent, and we do not know which is the best. What to do with these strategies? Just wait, who will succeed?
We offer - a public discussion of strategies to defeat aging. Roadmap contest. The closest thing now is to such a public discussion of X-prize, but hardly a degree of discussion corresponds to the importance of the issue.
Let us take the experience of conducting debates and election campaigns and holding the election of the best strategy for defeating aging.
For all this, we have created a resource that will analyze all approaches.
openlongevitystrategy.org
What might the debate look like in defense of a particular strategy? What questions will representatives of organizations answer?
- Are there obvious holes in the strategy? Are there any offers to jump the abyss in one step?
- Is it clear where the project will take the resources to implement the plan? It's about money, and about people, and about ideas.
- Will such a strategy lead to exponential growth in our area? Do not forget, we all live in a state of time pressure.
We also implement our own approach and offer it for criticism and discussion:
openlongevity.org
That is my main idea: let's choose the best approach in the fight against aging. It is important to take part in this.
The idea of prolonging life is often considered to be somehow selfish and self-centered. This is a huge misconception. The idea of extending life is the pinnacle of effective altruism. This is a struggle to save the lives of billions of people. The most important thing in this fight is a quality strategy. In any case, let us do this work together: we will choose and implement the best life extension strategy.
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